Loss of heterozygosity on chromosome 5q in ovarian cancer is frequently accompanied by TP53 mutation and identifies a tumour suppressor gene locus at 5q13.1-21
Open Access
- 1 July 1996
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 74 (1) , 115-119
- https://doi.org/10.1038/bjc.1996.324
Abstract
Forty-nine ovarian tumours were examined for loss of heterozygosity (LOH) on chromosome 5 using eight microsatellite markers spanning both arms, including one at the APC locus. LOH on 5q was a frequent event, detectable in 23 of 49 (47%) tumours, whereas 5p LOH was detected in only 1 of 22 tumours (5%). Six tumours showed partial LOH on 5q, enabling the candidate region to be localised to a 22 cM region proximal to APC, flanked by D5S424 and D5S644. An association was found between 5q LOH and TP53 mutation, with 18 of 23 (78%) tumours with LOH on 5q also harbouring a TP53 mutation. LOH on 5q was observed in 6 of 18 (33%) stage I tumours, suggesting that it may be an early event in the molecular pathogenesis of certain ovarian carcinomas.Keywords
This publication has 22 references indexed in Scilit:
- Mutation analysis of RASK and the ‘FLR exon’ of NF1 in sporadic ovarian carcinomaEuropean Journal Of Cancer, 1994
- The 1993–94 Généthon human genetic linkage mapNature Genetics, 1994
- A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1Human Molecular Genetics, 1994
- Loss of heterozygosity on chromosome 5 in sporadic ovarian carcinoma is a late event and is not associated with mutations in APC at 5q21-22Human Mutation, 1994
- Whole chromosome 17 loss in ovarian cancerGenes, Chromosomes and Cancer, 1993
- Spectrum of Mutation and Frequency of Allelic Deletion of the p53 Gene in Ovarian CancerJNCI Journal of the National Cancer Institute, 1993
- Allelic loss in ovarian cancerInternational Journal of Cancer, 1993
- Frequent somatic mutations of the APC gene in human pancreatic cancer.1992
- Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers.Proceedings of the National Academy of Sciences, 1992
- Revised FIGO staging for gynaecological cancerBJOG: An International Journal of Obstetrics and Gynaecology, 1989