Cyclosporine: GVHD and beyond

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Abstract
Graft-versus-host disease (GVHD) holds a dual place in contemporary medicine. Clinically, it presents a serious problem in histocompatible bone marrow transplantation, and it is the principal limitation to histoincompatible bone marrow transplantation. Biologically, GVHD is a model for diseases of autoimmunity and immune dysregulation. After bone marrow transplantation, GVHD can present as either of two clinical syndromes: the acute disease, which is characterized by the cytolytic destruction of the recipient's skin, gastrointestinal tract, and liver; or chronic GVHD, in which there are scleroderma-like changes in the skin, gastrointestinal tract, and liver and the development of autoantibodies in the presence of . . .