Etude expérimentale de la phototoxicité de l’essence de Bergamote

Publisher Website
Google Scholar
Abstract
Phototoxicity of bergamot oil in solar simulating radiation (SSR .gtoreq. nm) and in long UV radiation (UVA .gtoreq. 320 nm) was compared by studying photoaugmentation of erythema in the guinea pig after 24 h and pigmentary photoaugmentation in man on the 8th day. A close relationship exists between guinea pig and human responses, with both radiations used, and man seems to be slightly more sensitive to phototoxic effects of bergamot oil than the guinea pig. This difference of sensitivity necessarily implies the participation of UVA in the phototoxic reaction of bergamot oil with solar radiation. This UVA participation is particularly obvious in the guinea pig; in man, the results are less clear and a certain synergy of UVB rays (290-320 nm) may be involved in the phototoxic UVA-induced reaction of bergamot oil. Despite these slight differences, the erythematous reaction in the guinea pig appears to be a remarkable experimental model to demonstrate potential phototoxic reactions of products containing psoralens in man.

This publication has 2 references indexed in Scilit: