Die Osteomyelofibrose

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Abstract
Iron and erythrocyte kinetics were studied in nine cases of idiopathic osteomyelofibrosis with the aid of radioactive iron and chromium. A detailed description of the method is given. It was shown that the anemia which is almost always present is caused by hemolysis, reduced erythropoiesis or a combination of the two factors. Measurement of radioactivity on the body surface (liver, spleen, sacrum) enables the extramedullary erythropoiesis and the site of hemolysis to be determined and affords the indication for splenectomy if necessary. There is often evidence of iron wastage, indicative of the inadequate erythropoiesis. There are forms of osteomyelofibrosis with completely adequate extramedullary erythropoiesis and without increased destruction of erythrocytes, in which anemia only develops at a late stage.