A Model of L(+)-Lactate Metabolism in Normal Man
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in Annals of Nutrition and Metabolism
- Vol. 26 (4) , 254-263
- https://doi.org/10.1159/000176571
Abstract
Mathematical models were used to study the elimination of L(+)-lactate during and after an intravenous load of unlabelled sodium L(+)-lactate in 20 normal postprandial subjects. Clearance of L(+)-lactate from blood was 17.9 ± 1.1 ml (kg BW)-1 min-1 and the endogenous production rate of L(+)-lactate at rest was 1.38 ± 0.16 mol (70 kg BW)-1 24 h-1. Clearance and production were unchanged after a 36-hour fast in 4 subjects. Renal excretion of L(+)-lactate accounted for less than 1.2% of the infused load. Clearance of L(+)-lactate was closely related to the preinfusion concentrations of ketone bodies and alanine.Keywords
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