Die in vitro und in vivo Stabilität des Einschlusses von Methotrexat in negativ geladenen Liposomen nach Sterilfiltration/The in vitro and in vivo Stability of the Entrapment of Methotrexate in Negatively Charged Liposomes after Sterile Filtration

Open Access

1 February 1979

journal article
Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung C

Vol. 34 (1-2) , 114-119
https://doi.org/10.1515/znc-1979-1-223

Abstract

The preparation of sterile artificial liposomes (phosphatidylcholine: cholesterol: dicethylphos-phate = 5:5:1) by Millipore^® filtration is described. Conditions for storing liposome entrapped Methotrexate have been found which allow storage of the drug in the entrapped form over a period of at least 4 months. It is shown that intravenously injected liposome entrapped Methotrexate is retained for at least 15 hours in the particulate form. During this time no free Methotrexate is detectable in the blood.

Keywords

This publication has 0 references indexed in Scilit: