Double-blind, placebo-controlled trial of methylphenidate in older, depressed, medically ill patients

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Abstract
The authors examined the efficacy of methylphenidate in the treatment of depression in a group of older, medically ill patients. Sixteen patients underwent an 8-day double-blind, randomized, placebo-controlled crossover trial; 13 completed the trial. Statistically and clinically significant treatment responses were found. These results support the use of methylphenidate in older, medically ill patients in whom rapid resolution of depressive symptoms is crucial.