CARDIAC RESPONSE TO FLUID RESUSCITATION FROM HEMORRHAGIC-SHOCK

  • 1 January 1985
    • journal article
    • research article
    • Vol. 160  (5) , 444-452
Abstract
The cardiac hemodynamic and metabolic effects of several regimens of fluid resuscitation were compared. Nonsplenectomized dogs (30) subjected to 2 h of hemorrhagic shock were resuscitated with shed blood alone or in combination with plasma, saline solution or Ringer''s lactate solution. All regimens of volume replacement were equally effective in the initial resuscitation from severe shock. Correction of metabolic acidosis and decreased lactate production were comparable in all groups. During late resuscitation (180-200 min), cardiac hemodyamic and myocardial efficiency were significantly lower in the shed blood, plasma and saline solution groups. Ringer''s lactate solution is singularly effective in maintaining left ventricular performance despite similar preload, coronary blood flow and myocardial O2 delivery after all regimens of volume replacement.