Urea Therapy in Sickle-Cell Anemia

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Abstract
Since the first patient was treated with urea for sickle crisis over a year ago, controlled scientific data on its efficacy have been meager as compared to the information available from repetitive preliminary publications, oral presentations, news-media reports and even a book. No doubt, all this publicity has the salutary effect of focusing attention on the subject of sickle-cell anemia, the neglect of which has recently been pointed out.1 The questions for physicians to resolve still remain. Is urea treatment truly effective? Does its efficacy justify the hazards involved? Is it useful in all pain crises or in specific instances? . . .

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