Effect of Choline on Phosphatide Metabolism of Gholine-Deficient and Cholestero-Fed Rabbits.

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Abstract
In rabbits maintained on a high-fat, low-protein, choline-deficient diet for a period of 14 days, the synthesis of liver phosphatides was markedly increased above that in Purina-fed controls. A single dose of intravenous choline produced a further increment in phosphatide synthesis, but chronic choline supplements depressed it. Plasma phosphatide concentration and synthesis were markedly elevated in all of the fat-fed groups. Aortic phosphatide synthesis was not affected by fat feeding or choline deficiency. Choline administration to cholesterol-fed rabbits did not alter the plasma or liver phosphatide metabolism.

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