Antagonistic Effects of Acetylcholine and Nicotine on Isolated Frog Hearts
- 30 September 1958
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 195 (1) , 61-62
- https://doi.org/10.1152/ajplegacy.1958.195.1.61
Abstract
A study of the relationship between the actions of acetylcholine and nicotine on frog hearts indicates that both the excitatory and inhibitory effects of acetylcholine are antagonised by nicotine. Hearts stopped by acetylcholine and also spontaneously stopped hearts were restarted by nicotine. It has been suggested that exogenously administered acetylcholine and nicotine act through same receptors in a competitive manner.Keywords
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