Prediction of the Development of Hepato-Cellular-Carcinoma in Patients with Liver Cirrhosis by the Serial Determinations of Serum Alpha-L-fucosidase Activity.

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Abstract
Objective Evaluation of the usefulness of the serial daterminations of serum alpha-L-fucosidase (AFU) activity for prediction of the development of hepatocellular carcinoma (HCC) was performed. Methods and Patients Serum AFU activity was determined monthly for 42 months in 73 patients with liver cirrhosis (LC). Results HCC was diagnosed in 27 patients by means of ultrasonography during this observation period. In 23 (85%) of the 27 patients, serum AFU activity was found to exceed 700 nmole/ml/h during the LC stage. HCC developed within a few years in 23 (82%) of 28 LC patients with AFU activity exceeding 700 nmole/ml/h, in contrast, it developed in only 4 (9%) of 45 LC patients with AFU activity below 700 nmole/ml/h. AFU activity was already elevated in 23 (85%) of 27 patients at least 6 months before the detection of HCC by ultrasonography. Conclusion It is conceivable that the development of HCC can be predicted by means of serial determinations of serum AFU activity in patients with LC. (Internal Medicine 38: 927-931, 1999)

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