The genetic structure of mouse ornithine transcarbamylase
Open Access
- 25 February 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 16 (4) , 1593-1601
- https://doi.org/10.1093/nar/16.4.1593
Abstract
The gene encoding the mouse urea cycle enzyme, ornithine transcarbamylase has been isolated on five partially overlapping bacterlophage lambda clones. We have characterized the gene and found that it is split between ten exons distributed over approximately 70 kb of the X chromosone. The introns range in size from 88 bases to the relatively unusual size of approximately 26 kilobases, while the splice donor/splice acceptor sequences conform to the consensus established for other eukaryotic genes.Keywords
This publication has 25 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- Structure and Expression of a Complementary DNA for the Nuclear Coded Precursor of Human Mitochondrial Ornithine TranscarbamylaseScience, 1984
- Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.Proceedings of the National Academy of Sciences, 1983
- [2] New M13 vectors for cloningPublished by Elsevier ,1983
- Ornithine transcarbamylase in liver mitochondriaMolecular and Cellular Biochemistry, 1982
- Organization and Expression of Eucaryotic Split Genes Coding for ProteinsAnnual Review of Biochemistry, 1981
- The bidirectional transfer of DNA and RNA to nitrocellulose or diazobenzyloxymethyl-paperAnalytical Biochemistry, 1980
- In vitro synthesis of a putative precursor of mitochondrial ornithine transcarbamoylase.Proceedings of the National Academy of Sciences, 1979
- Screening λgt Recombinant Clones by Hybridization to Single Plaques in SituScience, 1977
- Citrulline synthesis in rat tissues and liver content of carbamoyl phosphate and ornithineBiochemical Journal, 1974