Influence of intracellular injection of H on the electrical coupling in cardiac Purkinje fibres

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Abstract
The effect of intracellular injection of H+ on the electrical coupling of canine Purkinje cells was investigated. It was found that H+ increased the intracellular resistance (ri) and caused electrical uncoupling. The effect of high (H+)i on cell communication was partially reverted by intracellular injection of EDTA. These observations seem to indicate that the effect of low pHi on the electrical coupling can be explained, at least in part, by a rise in free [Ca2+]i. Further studies are required.

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