T‐tubule swelling in hypertonic solutions: a freeze substitution study.

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Abstract
Striated muscles from Rana pipiens were exposed for variable periods of time to Ringer solutions made hypertonic by addition of either sucrose or NaCl. The muscles were rapid-frozen and prepared for EM by either freeze-substitution, freeze-fracture or cryoultramicrotomy. The only compartment greatly affected by hypertonicity is the transverse tubular system, which is visibly swollen. None of the elements of the sarcoplasmic reticulum increase in size.