Topical Beta-Aminopropionitrile in the Treatment of Peyronie’s Disease

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Abstract
Nine patients with Peyronie''s disease of 1-8 yr duration were treated with a 4- wk course of .beta.-aminopropionitrile free base as the pure liquid. The drug was applied topically to the plaques twice daily. Patients wee followed with ultrasound imaging of the plaques and saline inflations of the corpora cavernosa with photographic documentation of the deformity. No significant adverse effect was noted. Three patients experienced a subjective response but did not demonstrate objective change. Apparently, topical .beta.-aminopropionitrile was not effective in reversing the deformity of Peyronie''s disease. Further investigation into specific anticollagen drugs for the treatment of this condition may be warranted.

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