Regulation of the mevalonate pathway
- 1 February 1990
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 343 (6257) , 425-430
- https://doi.org/10.1038/343425a0
Abstract
The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.Keywords
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