Synthesis of Allenic Amino Acids via Chelate-Controlled Ester Enolate Claisen Rearrangement
- 31 December 1996
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1996 (12) , 1489-1493
- https://doi.org/10.1055/s-1996-4413
Abstract
Ester enolate Claisen rearrangement of amino acid propargylic esters 6 allows the synthesis of sensitive amino acids 8. This methodology is suitable not only for glycine derivatives but also for propargylic esters of various amino acids. In this case amino acids with quaternary α-carbon centers are formed.Keywords
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