Serum Thrombotic Accelerator (STA) Activity: Its Relation to the First Phase of Clotting.

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Abstract
Assay of serum thrombotic accelerator (STA) activity under standard conditions indicates that activation of Hageman Factor (HF), plasma thrombo-plastin antecedent (PTA), and Factor IX are necessary for STA elaboration. Moreover, STA activity does not depend on platelets or any other recognized coagulation factor with the possible exception of Ca++. Although essential in the donor serum for formation of this thrombotic moiety, HF, PTA, and Factor IX need not be present in the recipient animal for thrombus formation to occur. STA activity is distinct from Ca6++, HF, and PTA, and may not be identical with Factor IX; however, activation of HF appears to be the initial reaction required in the elaboration of this potent thrombotic agent that is distinct from thrombin and tissue thromboplastin.

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