QUANTITATIVE GLOMERULAR MORPHOLOGY OF THE NORMAL HUMAN-KIDNEY

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 49  (1) , 82-86
Abstract
Glomerular basement membrane (GBM) width (as the harmonic mean) and relative volumes of the glomerular mesangium and of its cellular and matrix components was determined in 59 male (73% living-related) and 59 female (93% living-related) donors of kidneys for transplantation. The GBM, consistently wider in male (mean, 373 nm.) vs. female (mean, 326 nm.) donors, increased in width in all dnors until the 4th decade of life when it appeared to decrease in width. The relative volume of the mesangium did not differ as to sex or age (mean, 14.2% of the glomerular volume), nor did neither of its components (mean cellular mesangium, 7.1%; mean matrix mesangium, 7.1%). No correlations were found among renal index, GBM width or the mesangium. No parameter differed in diabetic-related compared with nondiabetic-related donors. Results in cadavers for GBM width and the mesangium were no different from those of living-related donors. These observations yield insights into the development of the human kidney and its glomerular components, and in addition the GBM and mesangial measures will serve as normative values to which surgical or biopsy specimens can be related.