Red Cell and Saliva Studies for the Evaluation of ABH and Lewis Factors Among the Caucasian and Aboriginal Populations of Western Australia

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Abstract
The distribution of saliva genes Se and se was found to differ significantly between the Australian Aboriginal and Caucasian populations examined. No apparent variation was observed for the distribution of saliva genes Le and le. Subsequent studies revealed that the prediction of saliva nonsecretors of blood group substances ABH by Lea typing of the red cells alone were not considered as an accurate procedure when applied to the investigation of Australian Aborigines. Significant differences were also established for the frequency of the group A and group H antigen strength of the red cells between these 2 populations. Thus the findings revealed that the A antigen value was greater among the Caucasians possessing this blood group than among the Australian Aborigines possessing it. On the other hand, the red cells from blood group A Aborigines revealed a significantly greater range of H antigen reactivity than the Caucasians. Similar variations were also observed for the quantitative distribution of saliva substances H and Lea and it would appear that the Aborigines possess a much lower range of H substances in their saliva than the Caucasians, but a higher range of Lea substances. When the group A red cells of these 2 populations were tested against anti-H and anti-Leb was shown that the reactivity was directly dependent on the quantitative relationship of the A antigen strength observed on the red cells. The generally accepted view that all Leb antisera can be named as a form of anti-H simply because of their similarity of behavior was not confirmed in this study.

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