Recombination and the Properties of Tajima's D in the Context of Approximate-Likelihood Calculation

Open Access

1 December 2005

journal article
research article
Published by Oxford University Press (OUP) in Genetics

Vol. 171 (4) , 2143-2148
https://doi.org/10.1534/genetics.105.043786

Abstract

I show that Tajima's D, a commonly used summary of the site-frequency spectrum for single-nucleotide polymorphism data, is a biased summary of the site-frequency spectrum. Under neutral models, this bias depends on the population recombination rate. This bias of D in summarizing the data makes inference of demographic parameters sensitive to assumptions about recombination rates.

Keywords

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