THE ANTIDIURETIC POTENCY OF ARGININE AND LYSINE VASOPRESSINS IN THE PIG WITH OBSERVATIONS ON PORCINE RENAL FUNCTION1

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Abstract
In the dog intra-venous arginine vasopressin is a much more potent antidiuretic agent in terms of its vasopressor activity than lysine vasopressin. Arginine vasopressin appears to be the antidiuretic hormone of the dog and many other mammals whereas lysine vasopressin is the antidiuretic hormone of the pig. In the pig lysine vasopressin is as potent if not more potent than arginine vasopressin when either hormone is administered to unanesthetized animals by intravenous injection. Renal function studies were also performed in the pig which can excrete about 20 percent of the glomerular filtrate during water diuresis. The glomerular filtration rate (CIN), the renal plasma flow (CPAH) and the maximal transfer of para-aminohippurate (TmpAH) are all much higher in the pig than in most other mammals. The clearance of endogenous creatinine was lower than that of inulin.

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