ELEVATED SERUM LEVELS OF T3WITHOUT METABOLIC EFFECT IN NUTRITIONALLY DEFICIENT RATS, ATTRIBUTABLE TO REDUCED CELLULAR UPTAKE OF T3
- 1 August 1981
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 109 (2) , 673-675
- https://doi.org/10.1210/endo-109-2-673
Abstract
Rats receiving a nutritionally deficient diet displayed markedly elevated serum free T3 levels but showed no increase in oxygen consumption. This was associated with greatly reduced ratios of hepatic cellular and nuclear 125I-T3 to serum 125I-T3. Kinetic data supported the conclusion that cellular uptake of T3 was decreased in the nutritionally deficient rats. The lack of metabolic effect, despite the elevated serum T3 levels, is attributable to reduced availability of serum T3 to tissue nuclear receptor sites.Keywords
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