Decompensated Portal Cirrhosis
- 1 February 1966
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 117 (2) , 182-186
- https://doi.org/10.1001/archinte.1966.03870080026005
Abstract
IT HAS BEEN suggested that administration of large doses of vitamin K or its analogues over a prolonged period to adults with severe liver disease can be hazardous. Cases have been cited in which a normal Quick one-stage prothrombin time became abnormal, or a preexisting abnormality of the prothrombin time was increased if the patient receiving vitamin K or its analogues had chronic liver disease.1-8 In several instances 1-7 a hemorrhagic diathesis associated with profound hypoprothrombinemia was described. In one of these the bleeding was stated to be accompanied by significant alterations in liver function tests, and these complications were attributed to toxic properties of vitamin K.7 On the other hand, administration of large doses of vitamin K to patients with mild or moderate liver disease resulted in improvement of the Quick one-stage prothrombin time.1,3-5,8-10 Taine and Juvanon 11 reported favorable responses to vitamin K even inThis publication has 0 references indexed in Scilit: