Mechanism of dethiobiotin synthetase—characterisation of the 8-aminocarbamate of (7R,8S)-7,8 diaminononanoate as an enzyme-bound intermediate
- 1 January 1994
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 5,p. 559-560
- https://doi.org/10.1039/c39940000559
Abstract
Enzymatically catalysed formation of the ureido ring of dethiobiotin 2 from (7R, 8S)-7,8-diaminononanoate 3 by purified E. coli dethiobiotin synthetase involves the formal hydrolysis of one equivalent of ATP, a combination of substrate loading and trapping experiments show that the carbamate 5 is an intermediate in the synthesis of dethiobiotin from 3.Keywords
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