Preferential Acid-catalyzed Hydrolysis of the Formamide Linkage of N′-Formylkynurenine in Frozen Solution
- 1 December 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 80 (6) , 1287-1292
- https://doi.org/10.1093/oxfordjournals.jbchem.a131400
Abstract
Acid-catalyzed hydrolysis of the formamide linkage of N-acetyl-N'-formyl-L-kynurenineamide in frozen dilute hydrochloric acid solution followed first-order kinetics, yielding N-acetyl-L-kynurenineamide as the sole reaction product. The maximum rate of reaction in the frozen solution was found at around −7.5° and approximated that of the reaction in liquid solution at 40°. By freezing the dilute acid solution at −8° the reaction was accelerated by 60 times compared with that in super-cooled liquid solution at the same temperature.Keywords
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