Antiviral Nucleoside Analogues with Axial Chirality
- 1 July 1997
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 16 (7-9) , 1003-1012
- https://doi.org/10.1080/07328319708006123
Abstract
Chemistry and biological activity of nucleoside analogues comprising a chiral axis will be reviewed with emphasis on anti-HIV agent adenallene (1a) and anti-HIV/HBV analogue cytallene (1b). Possible mechanism of action, activity toward the enzymes of nucleic acid metabolism and structure-activity relationships will be discussed.Keywords
This publication has 17 references indexed in Scilit:
- Phosphodiester Amidates of Allenic Nucleoside Analogues: Anti-HIV Activity and Possible Mechanism of ActionJournal of Medicinal Chemistry, 1996
- (.+-.)-N9-(2-(Hydroxymethyl)spiro[3.3]hept-6-yl)adenine. The First Biologically Active Saturated Analog of Adenallene with Axial DissymmetryThe Journal of Organic Chemistry, 1995
- R,S-Adenallene 4′-phosphate: Substrate activity and enantioselectivity toward AMP deaminase and 5′-nucleotidaseBioorganic & Medicinal Chemistry Letters, 1995
- Synthesis, Absolute Configuration, and Enantioselectivity of Antiretroviral Effect of (R)-(-)- and (S)-(+)-Cytallene. Lipase-Catalyzed Enantioselective Acylations of (.+-.)-N4-AcylcytallenesJournal of Medicinal Chemistry, 1995
- Synthesis and Anti-HIV Activity of 5-Fluorocytallene: N-Dimethylaminomethylene as a Facilitating Group in Acetylene → Allene IsomerizationNucleosides and Nucleotides, 1994
- Synthesis of 2′,3′-Didehydro-2′,3′-Dideoxy-3′-C-Methyl Substituted NucleosidesNucleosides and Nucleotides, 1993
- (R)-(-)- and (S)-(+)-Adenallene: synthesis, absolute configuration, enantioselectivity of antiretroviral effect, and enzymic deamination.Journal of Medicinal Chemistry, 1992
- Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogsBiochemical and Biophysical Research Communications, 1991
- Synthesis of 2',3'-dideoxy-3'-C-hydroxymethyl nucleosides as potential inhibitors of HIVThe Journal of Organic Chemistry, 1991
- Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolaseJournal of Medicinal Chemistry, 1988