Determination of Plasma Levels of Bupivacaine by High-Performance Liquid Chromatography

1 September 1991

journal article
research article
Published by Taylor & Francis in Journal of Liquid Chromatography

Vol. 14 (15) , 2937-2949
https://doi.org/10.1080/01483919108049367

Abstract

We evaluate a method for determination of bupivacaine using HPLC, and the possibility of pharmacological interferences produced by seven commonly used drugs administered before, during and after surgery: diacepam, midazolam, epinephrine, naloxone, flumacenil, atropine and ephedrine. The method has an average recovery of 102.8 +/− 5.4%. The detection limit is 0.125 μg/mL. The within-day coefficient of variation is 5.88% and the between-day coefficient of variation is 15%. We haven't found drug interferences at generally encountered serum concentrations.

Keywords

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