Effects of the contraceptive pill on sedative responses to clonidine and apomorphine in normal women
- 1 May 1985
- journal article
- research article
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 15 (2) , 363-367
- https://doi.org/10.1017/s0033291700023655
Abstract
Synopsis: In normal women sedation following intravenous administration of the α2-adrenoceptor agonist clonidine (1·3 μg/kg) was significantly greater following 3 weeks' continuous treatment with the combined contraceptive pill than at the end of the 7-day withdrawal period. In contrast, sedative responses to the dopamine agonist apomorphine (5 μg/kg subcutaneously) were decreased when subjects were taking the contraceptive pill. These findings are in agreement with animal experimental studies, indicating that oestrogen can alter α-adrenoceptor and dopamine autoreceptor sensitivity. Such interactions may be involved in the effects of female sex steroids on mood.Keywords
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