Polymorphonuclear leukocyte motility in vitro. II. Stimulatory effect of monosodium urate crystals and urate in solution; partial inhibition by golchicine and indomethacin

Publisher Website
Google Scholar
Abstract
Studies were performed to determine the effect of monosodium urate crystals on motility of polymorphonuclear leukocytes (PMN's) in vitro, using a modification of the Boyden chamber technic. A stimulatory effect on the random motility of PMN's (not chemotaxis) was demonstrated which could be explained entirely on the basis of the urate in solution and could be blocked by uricase, colchicine, and indomethacin.