Abnormal excretion of .BETA.-aminoisobutyric acid in urine of the rats injected with 1-aminoproline and its stereospecificity.
Open Access
- 1 January 1978
- journal article
- Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry
- Vol. 42 (1) , 137-140
- https://doi.org/10.1271/bbb1961.42.137
Abstract
One of the unidentified ninhydrin positive substances abnormally excreted in urine of the rats injected with 1-aminoproline was characterized as β-aminoisobutyric acid. The absolute configuration of this amino acid was proved to be the (R)-form by means of a specific gas chromatographic technique. Excretion of (R)-β-aminoisobutyric acid reached a maximum during the interval from 3.5 to 5 hr after the intraperitoneal injection of 1-aminoproline. Spectacular accumulation of β-aminoisobutyric acid was observed in liver and kidney by the 1-aminoproline treatment. The amino acid accumulated in these tissues also had the (R)-form. These facts suggest that 1-aminoproline inhibits the stereospecific metabolism of the β-aminoisobutyric acid.Keywords
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