Binding of the 2F5 Monoclonal Antibody to Native and Fusion-Intermediate Forms of Human Immunodeficiency Virus Type 1 gp41: Implications for Fusion-Inducing Conformational Changes
Open Access
- 1 March 2004
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 78 (5) , 2627-2631
- https://doi.org/10.1128/jvi.78.5.2627-2631.2004
Abstract
We investigated how the broadly neutralizing monoclonal antibody 2F5 affects the human immunodeficiency virus type 1 envelope glycoprotein as it undergoes receptor-induced conformational changes and show that 2F5 binds both native and fusion-intermediate conformations, suggesting inhibition of a late step in virus entry. We also demonstrate conformational changes in the C heptad of gp41.Keywords
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