CLK‐1 protein has DNA binding activity specific to OL region of mitochondrial DNA
- 15 March 2002
- journal article
- Published by Wiley in FEBS Letters
- Vol. 516 (1-3) , 279-284
- https://doi.org/10.1016/s0014-5793(02)02568-1
Abstract
Mutations in the clk-1 gene of Caenorhabditis elegans extend worm life span and slow down a variety of physiological processes. Here we report that C. elegans CLK-1 as well as its mouse homologue have DNA binding activity that is specific to the OL region of mitochondrial DNA. DNA binding activity of CLK-1 is inhibited by ADP, and is altered by mutations that extend nematode life span. Our results suggest that, in addition to its enzymatic function in ubiquinone biosynthesis, CLK-1 is involved in the regulation of mtDNA replication or transcriptionKeywords
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