Tamoxifen Suppresses Gonadotropin-Induced 17α-Hydroxyprogesterone Accumulation in Normal Men
- 1 November 1980
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 51 (5) , 1026-1029
- https://doi.org/10.1210/jcem-51-5-1026
Abstract
Intramuscular administration of 1500 IU hCG daily for 3 days induced a transient accumulation of 17α-hydroxyprogesterone (17 OHP) relative to testosterone (T) in normal men, reaching its maximum 24 h after the first injection (17 OHP to T ratio, 1.7 ± 0.3 times baseline; P < 0.01). Simultaneous administration of hCG and the estrogen antagonist tamoxifen (20 mg twice daily) almost completely abolished the hCG-induced steroidogenic block localized between 17 OHP and T (17 OHP to T ratio at 24 h, 1.1 ± 0.1 times baseline; P*< 0.01 vs. hCG alone). These data indirectly suggest that, in man, the hCG-induced steroidogenic lesion might be mediated through its estrogenstimulating effect.Keywords
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