THE DISTRIBUTION OF BLOOD PERFUSATES IN CAPILLARY CIRCULATION

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Abstract
The capillary circulation was observed in the mesentery and tongue of the frog while the animal was being perfused. Solns. designed to replace the blood as a perfusion medium to be completely effective must not only contain appropriate chemical constituents but also a suspension of particulate matter, such as C or red blood cells. The beneficial action of the particulate matter lies, in part, in its ability to bring about a maximum distr. of the perfusate through all the vessels of the capillary bed. In the absence of red cells or C, the flow is restricted to the a-v capillaries. The disposition of the true capillaries at right angles to the parent trunk favors the development of suction forces, which gradually narrow the empty true capillaries. The addition of suspended particles sets up mechanical disturbances which divert the flow into the true capillaries. Particulate matter is also effective in delaying edema by plugging leaks in the walls of the vessels. Stasis clogs abnormally leaky vessels and acts to prevent further loss of fluid by blocking these vessels from the active circulation.

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