Chromosome Studies on Polyploid Cell Strains ofChinese HamsterIV: Duration of the Mitotic Cell Cycle

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Abstract
By autoradiographic methods, a study has been made of the duration of the mitotic cycle in a diploid-aneuploid cell line of the Chinese hamster and in polyploid lines derived from this line after treatment with colchicine. Compared with the diploid line, there is, in the stabilized polyploid lines, a clear lengthening of G2 stage only; the S and M stages, and probably also the G1 stage, undergo no significant variations. Before stabilizing their chromosome number on a modal value that is constant with time, the polyploid lines show a lengthening of the cell cycle in all its stages. Within the diploid-aneuploid line, the cells with a longer G2 stage, on the average reveal a greater number of small late-replicating chromosomes.