The Effect of Cardiac Pacing at High Rates on Plasma Enzyme Levels in the Anesthetized Dog

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Abstract
In pentobarbital-anesthetized dogs, cardiac pacing by an intra-atrial electrode at 240 beats/min resulted in small but significant increases in the plasma activity of glutamic–oxalacetic transaminase, which returned to control values within 30 min. No change in plasma creatine phosphokinase was observed following pacing. Possible mechanisms responsible for the release of tissue enzyme during pacing include an increase in rate of deformation of, and an increase in substrate transport by, the cardiac muscle plasma membrane.

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