The in vitro antibacterial activity of LY127935 (6059S), a novel 1-oxa-β-lactam antibiotic

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Abstract
The in vitro activity of LY127935 (6059S) was assessed against recent clinical isolates of common bacteria. It was highly active against the Enterobacteriaceae, with nearly all isolates inhibited by 1 mg/l, and was also highly active against Neisseria gonorrhoeae and Haemophilus influenzae, including β-lactamase-producing isolates. Its activity against Pseudomonas aeruginosa was notable in that it was about fourfold more active than carbenicillin against most isolates but was relatively much more active against highly carbenicillin-resistant isolates. It was generally more active than most cephalosporins against other pseudomonads and Acinetobacter spp. LY127935 was active, but less so than cephaloridine, against streptococci (other than Streptococcus faecalis against which it was inactive) and staphylococci, but methicillin-resistant staphylococci were resistant to it. Most isolates of Bacteroides fragilis and other species of Bacteroides were sensitive to LY127935, but there were a number of relatively resistant strains. LY127935 was resistant to hydrolysis by all the β-lactamases tested except one from a highly ampicillin-resistant strain of B. fragilis that hydrolysed the compound very slowly.

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