Change of External Urethral Sphincter Function in Prostatic Patients

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Abstract
External urethral function was urodynamically examined in 13 patients with benign prostatic hypertrophy (BPH) associated with chronic urinary retention and in 5 volunteers. Prevoiding drop in external urethral sphincter pressure was noted in all the volunteers, whereas it was not found in 6 of the 13 cases of BPH. Bladder neck opening pressure was higher in these 6 cases (p < 0.05). After administration of phentolamine, prevoiding drop was noted in 5 of these 6 cases and bladder neck opening pressure decreased so much that there was no significant intergroup difference. The above results mean that the increase in α-adrenergic receptors makes the prostate, which has been already hypertrophied, less elastic, inhibiting external urinary sphincter function.

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