Bis(methoxycarbonyl)carbene Insertion into N-H Bonds: A Facile Route toN-Substituted Aminomalonic Esters
- 1 January 1988
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1988 (09) , 721-723
- https://doi.org/10.1055/s-1988-27687
Abstract
Bis(methoxycarbonyl)carbene, generated by the copper(II)-catalyzed fragmentation of 2,5-dichlorothiophenium-1-bis(methoxycarbonyl) methylide (3) undergoes rapid and efficient insertion into the N-H bonds of primary and secondary amines to generate N-substituted aminomalonic esters in good to excellent yields.Keywords
This publication has 0 references indexed in Scilit: