Highly Enantio- and Diastereoselective Hetero-Diels-Alder Reactions Catalyzed by New Chiral Tridentate Chromium(III) Catalysts
- 16 August 1999
- journal article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 38 (16) , 2398-2400
- https://doi.org/10.1002/(sici)1521-3773(19990816)38:16<2398::aid-anie2398>3.0.co;2-e
Abstract
Even moderately nucleophilic dienes react with simple aldehydes in the presence of a new CrIII catalyst in a hetero‐Diels–Alder reaction [Eq. (1)]. Tetrahydropyranyl products with up to three stereogenic centers are generated in near‐perfect diastereoselectivities and with greater than 90 % ee (99 % ee for the example shown). TBAF=tetrabutylammonium fluoride; TBS=tert‐butyldimethylsilyl; TES=triethylsilyl.Keywords
This publication has 0 references indexed in Scilit: