On the Biological Assay of Gholecystokinin and Its Dosage in Cholecystography

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Abstract
The methods applied in assaying the biological activity of cholecystokinin are reviewed. The authors recommend the technique of Ivy as described in detail by Ivy and Janecek 1959. One Ivy dog unit of cholecystokinin per kg body weight is recommended as a suitable dose to be given intravenously in man in connection with cholecystographies. No better response will be obtained with larger doses. This calculated dose agrees well with the dose found empirically to be clinically sufficient as applied in about 2,000 cholecystographies performed in different Swedish clinics.