Efficient deprotection of NG-tosylarginine with a thioanisole–trifluoromethanesulphonic acid system
- 1 January 1980
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 22,p. 1063-1064
- https://doi.org/10.1039/c39800001063
Abstract
The tosyl group attached at the guanidino function of arginine can be efficiently cleaved by a thioanisole–trifluoromethanesulphonic acid system, which can deprotect O-2,6-dichlorobenzyltyrosine without the formation of O-to-C rearrangement products; the NG-mesitylene-2-sulphonyl group was also cleaved by a thioanisole–trifluoroacetic acid system.Keywords
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