Autoimmune Renal Disease; The Production of Autoimmune Renal Disease in the Rat by Homoimmunization with Organ-Heterologous Material

Publisher Website
Google Scholar
Abstract
Autoimmune renal disease was produced in rats by homoimmunization with organ homogenates incorporated into Freund''s complete adjuvant given intradermally over a prolonged period of time. About half the animals treated with species-homologous kidney and placenta developed autoimmune renal disease but only 3 out of 9 and 1 out of 11 rats receiving heart and lung, respectively, had evidence of kidney disease. No untoward effects of autoimmune renal disease upon pregnancy was recognized. Fertility was reduced in both experimental and control groups and was probably related to the effects of the adjuvant. One control rat, in which a retained macerated fetus and necro-tizing placentitis and panmetritis were found 6 weeks after abortion, had glomerulonephritis indistinguishable from autoimmune renal disease. The results of the experiments presented herein indicate that the isoantigen(s) responsible for stimulating the production of kidney-damaging autoantibodies by homoimmunization with organ homogenates is widespread in the rat organism.

This publication has 1 reference indexed in Scilit: