THE STATE OF HEMOGLOBIN IN SICKLED ERYTHROCYTES
Open Access
- 1 February 1966
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 123 (2) , 341-346
- https://doi.org/10.1084/jem.123.2.341
Abstract
Electron microscopic and other evidence have provided support for the hypothesis that the sickling phenomenon is due to the intracellular formation of long slender crystals of reduced sickle hemoglobin. The rapid growth of these crystals causing tenting of the cell membrane is responsible for the bizarre distortion of the erythrocytes and presumably for the disease itself.This publication has 10 references indexed in Scilit:
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