NEOPLASMS IN DOMESTIC-ANIMALS - A REVIEW OF EXPERIMENTAL AND SPONTANEOUS CARCINOGENESIS

  • 1 January 1981
    • journal article
    • review article
    • Vol. 54  (2) , 111-125
Abstract
Clues to environmental and host factors in human oncogenesis are derived from clinical or epidemiologic studies; additional evidence is provided by animal experimentation. Induced tumors in animals are useful because of their reproducibility and predictability, allowing detailed study of specific carcinogens or carcinogenic influences. Spontaneously or naturally occurring tumors in domestic animals are of particular interest for comparative studies. These tumors occur in heterogeneous outbred populations of animals closely sharing man''s environment; their cause is generally unknown and many tumors occur in numbers suitable for detailed investigations. Tumors generally occur in aged animals, facilitating study of chronic processes associated with carcinogenesis in nature.