Atrial Natriuretic Factor in the Landry–Guillain–Barré Syndrome

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Abstract
To the Editor: Atrial natriuretic factor (ANF) may have a physiologic role in cardiocirculatory homeostasis. In humans, synthetic α-ANF decreases blood pressure, produces an extravascular shift of fluid, and promotes diuresis and natriuresis.1 Endogenous plasma ANF increases in response to hypervolemia,2 which is thought to activate ANF release through atrial distention.3 The plasma ANF level has also been noted to rise during acute hypertension induced by the infusion of vasopressor hormones.4 However, whether spontaneous fluctuations in systemic blood pressure are accompanied by changes in ANF release has been unknown.Instability of blood pressure is a characteristic consequence of baroreflex dysfunction. . . .