Comparative in vitro activity of the new oxazolidinones DuP 721 and DuP 105 against Staphylococci and Streptococci
- 1 March 1989
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 8 (3) , 256-260
- https://doi.org/10.1007/bf01965273
Abstract
The in vitro activity of DuP 721 and DuP 105, two orally active members of the oxazolidinones, was compared with that of glycopeptides and ciprofloxacin against 185 gram-positive isolates. Ninety percent ofStaphylococcus aureus isolates, including penicillin- and methicillin-resistant strains, were inhibited by DuP 721 at 1 µg/ml and by DuP 105 at 16 µg/ml; DuP 721 inhibited 90% of coagulasenegative staphylococci tested at 1 µg/ml. The MIC90 forStreptococcus faecalis was 4 µg/ml with DuP 721 and 16 µg/ml with DuP 105; DuP 721 inhibited 90% of β-hemolytic streptococci of group A at 0.5 µg/ml. Similar results on selected strains were obtained by continuously recording the optical density of cultures.This publication has 6 references indexed in Scilit:
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