Selenium Deficiency Is Associated With Shedding of HIV-1–Infected Cells in the Female Genital Tract

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Abstract
Summary:Lymphomas in persons with AIDS are mostly B-cell types, but T-cell lymphomas have also been reported. We examined T-cell lymphoma risk in the 2-year period after AIDS onset by linking 302,834 adults with AIDS to cancer registry data. Of 6,788 cases of non-Hodgkin's lymphoma (NHL) with specified histologies, 96 (1.4%) were T-cell lymphomas. Assessment was based on clinical diagnosis and histology because T-cell marker data were inadequate, but when present, marker data supported the T-cell diagnosis. The relative risk of T-cell lymphoma, estimated by standardized incidence ratio, was 15.0 (95% confidence interval: 10.0-21.7). Risks were increased for all subtypes, including mycosis fungoides, peripheral lymphomas, cutaneous lymphomas, and adult T-cell leukemia/lymphoma (ATLL). HIV-related immunodeficiency could be important, but differences between the population developing AIDS and the general population (e. g., immigration from the Caribbean region for ATLL) might independently increase T-cell lymphoma risk. Address correspondence and reprint requests to Robert Biggar, VEB/NCI, 6120 Room 8014 Executive Blvd, Bethesda, MD 20852 U.S.A.; e-mail: [email protected] Manuscript received October 24, 2000; accepted November 17, 2000. © 2001 Lippincott Williams & Wilkins, Inc.